The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 111 kDa).
FunctionMay act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
Tissue specificityWidely expressed at low level. Expressed at higher level in thyroid and prostate.
Sequence similaritiesBelongs to the protein disulfide isomerase family. Contains 2 thioredoxin domains.