Overview

  • Product nameAnti-TXNRD1 antibody
    See all TXNRD1 primary antibodies
  • Description
    Goat polyclonal to TXNRD1
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Pig, Orangutan
  • Immunogen

    Synthetic peptide:

    TKRSGASILQAGC

    , corresponding to C terminal amino acids 635-647 of Human TXNRD1 (NP_003321.3).

  • Positive control
    • Human spleen and testis tissue; Human Placenta lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab111186 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 1 µg/ml. Predicted molecular weight: 71 kDa.
ELISA 1/32000.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • FunctionIsoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
  • Tissue specificityIsoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
  • Sequence similaritiesBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
    Contains 1 glutaredoxin domain.
  • DomainThe N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.
  • Post-translational
    modifications
    The N-terminus of isoform 5 is blocked.
    ISGylated.
  • Cellular localizationCytoplasm and Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • cytoplasmic antibody
    • Gene associated with retinoic and IFN-induced mortality 12 protein antibody
    • Gene associated with retinoic and interferon-induced mortality 12 protein antibody
    • Gene associated with retinoid IFN induced mortality 12 protein antibody
    • GRIM 12 antibody
    • GRIM-12 antibody
    • GRIM12 antibody
    • KDRF antibody
    • KM 102 derived reductase like factor antibody
    • KM-102-derived reductase-like factor antibody
    • MGC9145 antibody
    • Oxidoreductase antibody
    • Thioredoxin reductase 1 antibody
    • Thioredoxin reductase 1 cytoplasmic antibody
    • Thioredoxin reductase GRIM 12 antibody
    • Thioredoxin reductase TR1 antibody
    • TR 1 antibody
    • TR antibody
    • TR1 antibody
    • TRXR 1 antibody
    • TRXR1 antibody
    • TRXR1_HUMAN antibody
    • TXNR antibody
    • TXNRD 1 antibody
    • Txnrd1 antibody
    see all

Anti-TXNRD1 antibody images

  • ab111186, at 2.5µg/ml dilution, staining TXNRD1 in formalin-fixed, paraffin-embedded Human spleen tissue by Immunohistochemistry.
  • ab111186, at 2.5µg/ml dilution, staining TXNRD1 in formalin-fixed, paraffin-embedded Human testis tissue by Immunohistochemistry.
  • Anti-TXNRD1 antibody (ab111186) at 0.1 µg/ml + Human Placenta lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 71 kDa

References for Anti-TXNRD1 antibody (ab111186)

ab111186 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"