Overview

  • Product nameAnti-TYRO3 antibody [EPR4308]
    See all TYRO3 primary antibodies
  • Description
    Rabbit monoclonal [EPR4308] to TYRO3
  • Tested applicationsSuitable for: WB, IP, IHC-P, ICCmore details
    Unsuitable for: Flow Cyt
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human TYRO3.

  • Positive control
    • WB: Fetal brain, fetal hippocampus and MCF7 lysates IHC-P: Human brain tissue
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab109231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 97 kDa.
IP 1/10 - 1/100.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Heat up to 98 °C, below boiling, and then let cool for 10-20 minutes.
ICC 1/500 - 1/1000.
  • Application notesIs unsuitable for Flow Cyt.
  • Target

    • FunctionMay be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.
    • Tissue specificityAbundant in the brain and lower levels in other tissues.
    • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
      Contains 2 fibronectin type-III domains.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • Cellular localizationCell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Brt antibody
      • BYK antibody
      • DTK antibody
      • RSE antibody
      • SKY antibody
      • Tif antibody
      • tyro3 antibody
      • TYRO3_HUMAN antibody
      • Tyrosine-protein kinase byk antibody
      • Tyrosine-protein kinase DTK antibody
      • Tyrosine-protein kinase receptor TYRO3 antibody
      • Tyrosine-protein kinase RSE antibody
      • Tyrosine-protein kinase SKY antibody
      see all

    Anti-TYRO3 antibody [EPR4308] images

    • Immunohistochemical analysis of TYRO3 in paraffin embedded Human brain tissue, using ab109231 at a 1/100 dilution.
    • All lanes : Anti-TYRO3 antibody [EPR4308] (ab109231) at 1/1000 dilution

      Lane 1 : fetal brain lysates
      Lane 2 : fetal hippocampus lysates
      Lane 3 : MCF7 cell lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 97 kDa

    References for Anti-TYRO3 antibody [EPR4308] (ab109231)

    This product has been referenced in:
    • Szymanska E  et al. Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway. Cell Signal 28:160-71 (2016). WB ; Human . Read more (PubMed: 26475677) »
    • Jiang L  et al. Selective activation of CB2 receptor improves efferocytosis in cultured macrophages. Life Sci 161:10-8 (2016). WB ; Mouse . Read more (PubMed: 27474129) »

    See all 3 Publications for this product

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"