Overview

  • Product name
    Anti-TYRO3 antibody [EPR4308]
    See all TYRO3 primary antibodies
  • Description
    Rabbit monoclonal [EPR4308] to TYRO3
  • Tested applications
    Suitable for: WB, IP, IHC-P, ICCmore details
    Unsuitable for: Flow Cyt
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human TYRO3.

  • Positive control
    • WB: Fetal brain, fetal hippocampus and MCF7 lysates IHC-P: Human brain tissue
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab109231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 97 kDa.Can be blocked with TYRO3 peptide (ab218119).
IP 1/10 - 1/100.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Heat up to 98 °C, below boiling, and then let cool for 10-20 minutes.
ICC 1/500 - 1/1000.
  • Application notes
    Is unsuitable for Flow Cyt.
  • Target

    • Function
      May be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.
    • Tissue specificity
      Abundant in the brain and lower levels in other tissues.
    • Sequence similarities
      Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
      Contains 2 fibronectin type-III domains.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • Cellular localization
      Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Brt antibody
      • BYK antibody
      • DTK antibody
      • Etk-2 antibody
      • protein tyrosine kinase 3 antibody
      • Rek antibody
      • RSE antibody
      • SKY antibody
      • Tif antibody
      • tyro3 antibody
      • TYRO3 protein tyrosine kinase antibody
      • TYRO3_HUMAN antibody
      • Tyrosine-protein kinase byk antibody
      • Tyrosine-protein kinase DTK antibody
      • Tyrosine-protein kinase receptor TYRO3 antibody
      • Tyrosine-protein kinase RSE antibody
      • Tyrosine-protein kinase SKY antibody
      • Tyrosine-protein kinase TIF antibody
      see all

    Images

    • Immunohistochemical analysis of TYRO3 in paraffin embedded Human brain tissue, using ab109231 at a 1/100 dilution.
    • All lanes : Anti-TYRO3 antibody [EPR4308] (ab109231) at 1/1000 dilution

      Lane 1 : fetal brain lysates
      Lane 2 : fetal hippocampus lysates
      Lane 3 : MCF7 cell lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 97 kDa

    References

    This product has been referenced in:
    • Szymanska E  et al. Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway. Cell Signal 28:160-71 (2016). WB ; Human . Read more (PubMed: 26475677) »
    • Jiang L  et al. Selective activation of CB2 receptor improves efferocytosis in cultured macrophages. Life Sci 161:10-8 (2016). WB ; Mouse . Read more (PubMed: 27474129) »

    See all 3 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab109231.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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