Anti-Tyrosine Hydroxylase antibody (ab106806)


  • Product nameAnti-Tyrosine Hydroxylase antibody
    See all Tyrosine Hydroxylase primary antibodies
  • Description
    Goat polyclonal to Tyrosine Hydroxylase
  • SpecificityThis antibody is expected to recognise all three reported isoforms (as represented by NP_954986.2; NP_000351.2; NP_954987.2).
  • Tested applicationsSuitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Dog, Pig
  • Immunogen

    Synthetic peptide:


    , corresponding to C terminal amino acids 513-524 of Human Tyrosine Hydroxylase (NP_954986.2; NP_000351.2; NP_954987.2).

  • Positive control
    • Human Brain (Cerebral Cortex) lysates



Our Abpromise guarantee covers the use of ab106806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 - 4 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 59 kDa).
IHC-Fr Use a concentration of 0.1 - 0.3 µg/ml.


  • FunctionPlays an important role in the physiology of adrenergic neurons.
  • Tissue specificityMainly expressed in the brain and adrenal glands.
  • PathwayCatecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • Involvement in diseaseDefects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • Sequence similaritiesBelongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dystonia 14 antibody
    • DYT14 antibody
    • DYT5b antibody
    • EC antibody
    • OTTHUMP00000011225 antibody
    • OTTHUMP00000011226 antibody
    • ple antibody
    • Protein Pale antibody
    • TH antibody
    • The antibody
    • TY3H_HUMAN antibody
    • TYH antibody
    • Tyrosine 3 hydroxylase antibody
    • Tyrosine 3 monooxygenase antibody
    • Tyrosine 3-hydroxylase antibody
    • Tyrosine 3-monooxygenase antibody
    • Tyrosine hydroxylase antibody
    see all

Anti-Tyrosine Hydroxylase antibody images

  • Predicted band size : 59 kDa
  • Anti-Tyrosine Hydroxylase antibody (ab106806) at 2 µg/ml + Human Cerebral Cortex lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 59 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)
  • ab106806 staining Tyrosine Hydroxylase in the following tissues, human hypothalamic supraoptic (SO), paraventricular (Pa) and periventricular (Pe) nuclei. Antigen retrieval with citrate buffer pH 6 at 80oC for 30 minutes.

References for Anti-Tyrosine Hydroxylase antibody (ab106806)

ab106806 has not yet been referenced specifically in any publications.

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