Anti-Tyrosine Hydroxylase (phospho S40) antibody (ab51206)


  • Product nameAnti-Tyrosine Hydroxylase (phospho S40) antibody
    See all Tyrosine Hydroxylase primary antibodies
  • Description
    Rabbit polyclonal to Tyrosine Hydroxylase (phospho S40)
  • Specificityab51206 detects endogenous levels of Tyrosine.
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthesized phosphopeptide derived from human Tyrosine Hydroxylase around the phosphorylation site of serine 40 (R-Q-SP-L-I).

  • Positive control
    • Human brain tissue; extracts from RAW264.7 cells.


Associated products


Our Abpromise guarantee covers the use of ab51206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/300 - 1/1000. Detects a band of approximately 59 kDa (predicted molecular weight: 59 kDa).
ELISA 1/40000.
IHC-P Use at an assay dependent concentration.


  • FunctionPlays an important role in the physiology of adrenergic neurons.
  • Tissue specificityMainly expressed in the brain and adrenal glands.
  • PathwayCatecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • Involvement in diseaseDefects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • Sequence similaritiesBelongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dystonia 14 antibody
    • DYT14 antibody
    • DYT5b antibody
    • EC antibody
    • OTTHUMP00000011225 antibody
    • OTTHUMP00000011226 antibody
    • ple antibody
    • Protein Pale antibody
    • TH antibody
    • The antibody
    • TY3H_HUMAN antibody
    • TYH antibody
    • Tyrosine 3 hydroxylase antibody
    • Tyrosine 3 monooxygenase antibody
    • Tyrosine 3-hydroxylase antibody
    • Tyrosine 3-monooxygenase antibody
    • Tyrosine hydroxylase antibody
    see all

Anti-Tyrosine Hydroxylase (phospho S40) antibody images

  • This image shows human brain tissue stained with ab51206 at a dilution of 1/50-1/100. Right hand image: treated with immunising peptide; left hand image: untreated.
  • All lanes : Anti-Tyrosine Hydroxylase (phospho S40) antibody (ab51206)

    Lane 1 : Extracts from RAW264.7 cells treated with UV (30min) with immunising peptide
    Lane 2 : Extracts from RAW264.7 cells treated with UV (30min) with no immunising peptide

    Predicted band size : 59 kDa

References for Anti-Tyrosine Hydroxylase (phospho S40) antibody (ab51206)

This product has been referenced in:
  • Beccano-Kelly DA  et al. LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory. Hum Mol Genet 24:1336-49 (2015). Read more (PubMed: 25343991) »

See 1 Publication for this product

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