Anti-Tyrosine Hydroxylase (phospho S8) antibody (ab60969)

Overview

  • Product nameAnti-Tyrosine Hydroxylase (phospho S8) antibody
    See all Tyrosine Hydroxylase primary antibodies
  • Description
    Rabbit polyclonal to Tyrosine Hydroxylase (phospho S8)
  • SpecificityDetects endogenous levels of Tyrosine Hydroxylase only when phosphorylated at serine 8.
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from human Tyrosine Hydroxylase around the phosphorylation site of serine 8 (A-P-SP-P-Q).

  • Positive control
    • Brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab60969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
IHC-P 1/50 - 1/100.

Target

  • FunctionPlays an important role in the physiology of adrenergic neurons.
  • Tissue specificityMainly expressed in the brain and adrenal glands.
  • PathwayCatecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • Involvement in diseaseDefects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • Sequence similaritiesBelongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dystonia 14 antibody
    • DYT14 antibody
    • DYT5b antibody
    • EC 1.14.16.2 antibody
    • OTTHUMP00000011225 antibody
    • OTTHUMP00000011226 antibody
    • ple antibody
    • Protein Pale antibody
    • TH antibody
    • The antibody
    • TY3H_HUMAN antibody
    • TYH antibody
    • Tyrosine 3 hydroxylase antibody
    • Tyrosine 3 monooxygenase antibody
    • Tyrosine 3-hydroxylase antibody
    • Tyrosine 3-monooxygenase antibody
    • Tyrosine hydroxylase antibody
    see all

Anti-Tyrosine Hydroxylase (phospho S8) antibody images

  • ab60969 at 1/50 - 1/100 dilution staining Tyrosine Hydroxylase in human brain by immunohistochemistry on paraffin-embedded tissue, in the absence or presence of the immunizing phosphopeptide.

References for Anti-Tyrosine Hydroxylase (phospho S8) antibody (ab60969)

ab60969 has not yet been referenced specifically in any publications.

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