Anti-Tyrosyl tRNA synthetase antibody (ab155504)

Overview

  • Product name
    Anti-Tyrosyl tRNA synthetase antibody
    See all Tyrosyl tRNA synthetase primary antibodies
  • Description
    Rabbit polyclonal to Tyrosyl tRNA synthetase
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 307-528 of Human Tyrosyl tRNA synthetase (Uniprot ID: P54577).

  • Positive control
    • 293T, A431, H1299, HeLaS3, MOLT4, Raji whole cell lysates; A431 cells
  • General notes
    Keep as a concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab155504 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 59 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
  • Involvement in disease
    Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
  • Sequence similarities
    Belongs to the class-I aminoacyl-tRNA synthetase family.
    Contains 1 tRNA-binding domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMTDIC antibody
    • SYYC_HUMAN antibody
    • Tyrosine tRNA ligase, cytoplasmic antibody
    • Tyrosine tRNA ligase 1, cytoplasmic antibody
    • Tyrosyl tRNA synthetase antibody
    • Tyrosyl--tRNA ligase antibody
    • Tyrosyl-tRNA synthetase, cytoplasmic antibody
    • TyrRS antibody
    • yars antibody
    • YRS antibody
    • YTS antibody
    see all

Images

  • Anti-Tyrosyl tRNA synthetase antibody (ab155504) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 59 kDa
  • Immunofluorescent analysis of methanol-fixed A431 cells labeling Tyrosyl tRNA synthetase with ab155504 at 1/200 dilution. Lower panel co-stained with Hoechst 33342.

References

ab155504 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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