Overview

  • Product nameAnti-TYSND1 antibody
  • Description
    Rabbit polyclonal to TYSND1
  • Tested applicationsSuitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    antigen sequence ATQETCPYDI AVVSLEEDLD DVPIPVPAEH FHEGEAVSVV GFGVFGQSCG PSVTSGILSA VVQVNGTPVM LQTTCAV, corresponding to amino acids 400-476 of Human TYSND1 (Isoform 1).

  • Positive control
    • Human small intestine U 251 MG cell line lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab122106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250 - 1/500.
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

Target

  • FunctionPeroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and the specific processing of PTS1 proteins. May participate to a regulatory mechanism that control the peroxisomal beta-oxidation of fatty acids.
  • Sequence similaritiesBelongs to the peptidase S1B family.
  • Post-translational
    modifications
    Processed into the 49 kDa and the 10 kDa forms upon import into the peroxisomes. The 49 kDa form probably corresponds to the mature enzyme, while the 10 kDa form may represent an inhibitory N-terminal fragment which prevents protease activity until it reaches the peroxisomes.
  • Cellular localizationPeroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • 49 kDa form antibody
    • EC 3.4.21.- antibody
    • FLJ40378 antibody
    • MGC131934 antibody
    • MGC34695 antibody
    • NET41 antibody
    • OTTHUMP00000019737 antibody
    • OTTHUMP00000019738 antibody
    • Peroxisomal leader peptide-processing protease antibody
    • Trypsin domain containing 1 antibody
    • Trypsin domain-containing protein 1 antibody
    • TYSD1_HUMAN antibody
    • TYSND1 antibody
    see all

Anti-TYSND1 antibody images

  • Immunofluorescent staining of Human cell line U-251MG shows positivity in nucleus but not nucleoli and centrosome. Recommended concentration of ab122106 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • All lanes : Anti-TYSND1 antibody (ab122106) at 1/250 dilution

    Lane 1 : RT 4 cell line lysate
    Lane 2 : U 251 MG cell line lysate
    Lane 3 : Human plasma
    Lane 4 : Human liver tissue lysate
    Lane 5 : Human tonsil tissue lysate
  • ab122106, at 1/50, staining TYSND1 in paraffin embedded Human small intestine by Immunohistochemistry.

References for Anti-TYSND1 antibody (ab122106)

ab122106 has not yet been referenced specifically in any publications.

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