Selective PGI2 and TXA2 synthase inhibitor. PGH2 analog.
Biological descriptionSelective inhibitor of PGI2 synthase (IC50 = 2 μM) and TXA2 synthase. PGH2 analog. Partial agonist at TP receptors.
Chemical name9α,11α-Azoprosta-5Z,13E-dien-1-oic acid
Storage instructionsStore at -20°C (desiccating conditions).
Solubility overviewSupplied in methyl acetate (5 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Li YC et al. Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change. J Biol Chem283:2917-26 (2008).
Read more (PubMed: 18032380) »
Gluais P et al. In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. Am J Physiol Heart Circ Physiol291:H2255-64 (2006).
Read more (PubMed: 16798820) »
Zou M et al. Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. Br J Pharmacol126:1283-92 (1999).
Read more (PubMed: 10217520) »
Mukhopadhyay A et al. Effect of trimetoquinol analogs for antagonism of endoperoxide/thromboxane A2-mediated responses in human platelets and rat aorta. J Pharmacol Exp Ther232:1-9 (1985).
Read more (PubMed: 3855323) »