Overview

  • Product name
    U 73122
  • Description
    Standard phospholipase C (PLC) inhibitor
  • Biological description
    Standard phospholipase C inhibitor (PLC) (IC50 = ~6 µM at PLC-β3). Shows a variety of biological activities including antiplatelet activation, Ca2+ signaling modulation and inhibition of 5-lipoxygenase activity. Active in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
  • Molecular weight
    464.65
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C29H40N2O3
  • CAS Number
    112648-68-7
  • PubChem identifier
    104794
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC
  • Source

    Synthetic

References

This product has been referenced in:
  • Liang WZ  et al. The mechanism of honokiol-induced intracellular Ca(2+) rises and apoptosis in human glioblastoma cells. Chem Biol Interact 221C:13-23 (2014). Read more (PubMed: 25106108) »
  • Shen W  et al. The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. J Nutr 143:584-90 (2013). Read more (PubMed: 23468551) »
  • Burgdorf C  et al. U73122, an aminosteroid phospholipase C inhibitor, is a potent inhibitor of cardiac phospholipase D by a PIP2-dependent mechanism. J Cardiovasc Pharmacol 55:555-9 (2010). Read more (PubMed: 20179606) »
  • Wilsher NE  et al. The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium. Drug Metab Dispos 35:1017-22 (2007). Read more (PubMed: 17403917) »
  • Hou C  et al. In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions. J Pharmacol Exp Ther 309:697-704 (2004). Read more (PubMed: 14730005) »
  • Muto Y  et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther 282:1379-88 (1997). Read more (PubMed: 9316850) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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