Overview

  • Product name
    U 93631
  • Description
    GABAA antagonist
  • Biological description
    GABAA antagonist that interacts with the picrotoxin site and stabilizes the GABAA receptor/Cl- channel complex in an inactivated state. Causes rapid decay of gamma-aminobutyric acid-induced chloride currents.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Bell-Horner CL  et al. Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABA(A) receptors. Brain Res Mol Brain Res 76:47-55 (2000). Read more (PubMed: 10719214) »
  • Dillon GH  et al. [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J Pharmacol Exp Ther 272:597-603 (1995). Read more (PubMed: 7531762) »
  • Dillon GH  et al. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors. Mol Pharmacol 44:860-5 (1993). Read more (PubMed: 8232235) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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