Biological descriptionPotent and selective D3 antagonist (Ki values are 160, 2281 and >10000 nM for hD3, D2 and D4 receptors, respectively).
Chemical name2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for U 99194 maleate (PNU 99194) (ab120570)
This product has been referenced in:
Li C et al. Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin. J Neurosci Res88:2513-23 (2010).
Read more (PubMed: 20623619) »
Casarrubea M et al. Effects of 7-OH-DPAT and U 99194 on the behavioral response to hot plate test, in rats. Physiol Behav89:552-62 (2006).
Read more (PubMed: 16919688) »
Audinot V et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther287:187-97 (1998).
Read more (PubMed: 9765337) »