Overview

  • Product name
  • Description
    Goat polyclonal to U2AF1L3
  • Specificity
    ab80607 is expected to recognise isoforms 1 and 2 (NP_001035515.1 and NP_659424.2). No cross-reactivity with U2AF1 expected.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide:

    C-EDGERAVAELSNR

    , corresponding to internal sequence amino acids 121 - 133 of Human U2AF1L3 (NP_001035515.1 and NP_659424.2)

  • Positive control
    • Human Cerebellum lysate and lung lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab80607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1/32000
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 26 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site.
    • Tissue specificity
      Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.
    • Sequence similarities
      Belongs to the splicing factor SR family.
      Contains 2 C3H1-type zinc fingers.
      Contains 1 RRM (RNA recognition motif) domain.
    • Domain
      The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
    • Cellular localization
      Nucleus. Nucleus speckle.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ35525 antibody
      • MGC33901 antibody
      • Splicing factor U2AF 26 kDa subunit antibody
      • U2 auxiliary factor 26 antibody
      • U2 small nuclear RNA auxiliary factor 1 like 3 antibody
      • U2 small nuclear RNA auxiliary factor 1 like 4 antibody
      • U2 small nuclear RNA auxiliary factor 1 like protein 3 antibody
      • U2 small nuclear RNA auxiliary factor 1 like protein 4 antibody
      • U2 small nuclear RNA auxiliary factor 1-like protein 3 antibody
      • U2 small nuclear RNA auxiliary factor 1-like protein 4 antibody
      • U2(RNU2) small nuclear RNA auxiliary factor 1 like 3 antibody
      • U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 antibody
      • U2AF1 like protein 3 antibody
      • U2AF1 RS3 antibody
      • U2AF1-like protein 3 antibody
      • U2AF1L3V1 antibody
      • U2AF1L4 antibody
      • U2AF1RS3 antibody
      • U2af26 antibody
      • U2AF4_HUMAN antibody
      • U2RNU2 small nuclear RNA auxiliary factor 1 like 3 antibody
      • U2RNU2 small nuclear RNA auxiliary factor 1 like protein 3 antibody
      see all

    Images

    References

    ab80607 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab80607.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up