Our Abpromise guarantee covers the use of ab50986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 50 kDa.
Dot Blot Use at an assay dependent dilution.


  • FunctionComponent of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
    Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2 and THOC4.
  • Sequence similaritiesBelongs to the DEAD box helicase family. DECD subfamily.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • DomainThe helicase C-terminal domain mediates interaction with THOC4.
  • Cellular localizationNucleus. Nucleus speckle.
  • Information by UniProt
  • Database links
  • Alternative names
    • 0610030D10Rik antibody
    • 4F2-LC6 antibody
    • 56 kDa U2AF65-associated protein antibody
    • AI428441 antibody
    • ATP-dependent RNA helicase p47 antibody
    • B(0,+)-type amino acid transporter 1 antibody
    • BAT1 antibody
    • Bat1a antibody
    • D17H6S81E antibody
    • D17H6S81E-1 antibody
    • D6S81E antibody
    • D6S81Eh antibody
    • DDX39B antibody
    • DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B antibody
    • DEAD box protein UAP56 antibody
    • DX39B_HUMAN antibody
    • EC 3.6.1.- antibody
    • Glycoprotein-associated amino acid transporter b0,+AT1 antibody
    • HLA-B-associated transcript 1 protein antibody
    • HLA-B-associated transcript 1A antibody
    • HLA-B-associated transcript-1 antibody
    • MGC127051 antibody
    • MGC19235 antibody
    • MGC38799 antibody
    • nuclear RNA helicase (DEAD family) antibody
    • OTTHUMP00000029229 antibody
    • OTTHUMP00000165889 antibody
    • OTTHUMP00000165890 antibody
    • p47 antibody
    • Solute carrier family 7 member 9 antibody
    • Spliceosome RNA helicase BAT1 antibody
    • Spliceosome RNA helicase DDX39B antibody
    • U2AF65-associayed protein, 56-KD antibody
    • UAP56 antibody
    see all

Anti-UAP56 antibody [2060C10a] images

References for Anti-UAP56 antibody [2060C10a] (ab50986)

ab50986 has not yet been referenced specifically in any publications.

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