Overview

  • Product nameAnti-UBE2V1 antibody
    See all UBE2V1 primary antibodies
  • Description
    Rabbit polyclonal to UBE2V1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chicken, Cow, Orangutan
  • Immunogen

    Synthetic peptide:

    GTVSWGLEDD EDMTLTRWT

    conjugated to KLH, corresponding to amino acids 31-49 of Human UBE2V1 (NP_954595.1)

  • Positive control
    • Human thyroid tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab89903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 26 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionHas no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
  • Tissue specificityHighly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
  • Sequence similaritiesBelongs to the ubiquitin-conjugating enzyme family.
  • Cellular localizationNucleus. Excluded from the nucleolus.
  • Information by UniProt
  • Database links
  • Alternative names
    • CIR1 antibody
    • CROC-1 antibody
    • CROC1 antibody
    • CROC1A antibody
    • TRAF6-regulated IKK activator 1 beta Uev1A antibody
    • UB2V1_HUMAN antibody
    • UBE2V 1 antibody
    • UBE2V antibody
    • UBE2V1 antibody
    • Ubiquitin conjugating enzyme E2 variant 1 antibody
    • Ubiquitin-conjugating enzyme E2 variant 1 antibody
    • UEV-1 antibody
    • UEV1 antibody
    see all

Anti-UBE2V1 antibody images

  • ab89903 at 5µg/ml staining UBE2V1 in Human thyroid by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

References for Anti-UBE2V1 antibody (ab89903)

ab89903 has not yet been referenced specifically in any publications.

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