Overview

  • Product name
  • Description
    Rabbit polyclonal to UBIAD1
  • Specificity
    ab93413 reacts with residues 32-45 [PEQDRLPQRSWRQK] of UBIAD1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Reacts with residues 32-45 (

    PEQDRLPQRSWRQK

    ) of the 37kDa human TERE1 protein

Properties

Applications

Our Abpromise guarantee covers the use of ab93413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/500. Predicted molecular weight: 37 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas. Mediates the conversion of phylloquinone (PK) into menaquinone-4 (MK-4), probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4.
    • Tissue specificity
      Ubiquitously expressed.
    • Pathway
      Cofactor biosynthesis; menaquinone biosynthesis.
    • Involvement in disease
      Defects in UBIAD1 are the cause of crystalline corneal dystrophy of Schnyder (SCCD) [MIM:121800]. SCCD is a rare autosomal dominant disease characterized by progressive corneal opacification resulting from abnormal deposition of cholesterol and phospholipids.
    • Sequence similarities
      Belongs to the ubiA prenyltransferase family.
    • Cellular localization
      Endoplasmic reticulum membrane. Cytoplasm. Nucleus. Mitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • RP4-796F18.1 antibody
      • SCCD antibody
      • TERE 1 antibody
      • tere1 antibody
      • Transitional epithelia response protein antibody
      • Transitional epithelial response protein 1 antibody
      • UbiA prenyltransferase domain containing 1 antibody
      • UbiA prenyltransferase domain containing protein 1 antibody
      • UbiA prenyltransferase domain-containing protein 1 antibody
      • UBIA1_HUMAN antibody
      • UBIAD 1 antibody
      • Ubiad1 antibody
      see all

    References

    ab93413 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Thank you for your reply.

    Can you describe the image that you had sent with the WB. Are the left 5 wells from rats with chronic kidney disease? Are the homogenates rat kidney? What are the control lanes?

    We have heard from 1 customer ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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