Overview

  • Product nameAnti-UBR1 antibody
    See all UBR1 primary antibodies
  • Description
    Mouse monoclonal to UBR1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: ADEEAGGTER MEISAELPQT PQRLASWWDQ QVDFYTAFLH HLAQLVPEIY FAEMDPDLEK QEESVQMSIF TPLEWYLFGE DPDICLEKLK HSGAFQLCG, corresponding to amino acids 2-101 of Human UBR1

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionE3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
    • Tissue specificityBroadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
    • PathwayProtein modification; protein ubiquitination.
    • Involvement in diseaseDefects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS) [MIM:243800]. This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis.
    • Sequence similaritiesBelongs to the UBR1 family.
      Contains 1 RING-type zinc finger.
      Contains 1 UBR-type zinc finger.
    • Developmental stageExpressed in fetal pancreas.
    • DomainThe RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm > cytosol.
    • Information by UniProt
    • Database links
    • Alternative names
      • E3 ubiquitin-protein ligase UBR1 antibody
      • JBS antibody
      • N-recognin-1 antibody
      • ubiquitin protein ligase E3 component n-recognin 1 antibody
      • Ubiquitin-protein ligase E3-alpha-1 antibody
      • Ubiquitin-protein ligase E3-alpha-I antibody
      • UBR1 antibody
      • UBR1_HUMAN antibody
      see all

    Anti-UBR1 antibody images



    • Predicted band size : 200 kDa
      UBR1 antibody (ab58117) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-UBR1 antibody (ab58117)

    ab58117 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58117.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"