Overview

  • Product name
  • Description
    Goat polyclonal to UBR4
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human UBR4 aa 5002-5015 (C terminal) (Cysteine residue). The exact sequence is proprietary. NP_065816.2.
    Sequence:

    NTTRATSREEKNLQ


    Database link: Q5T4S7

  • Positive control
    • Human spleen tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab187879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the UBR4 family.
    Contains 1 UBR-type zinc finger.
  • Cellular localization
    Membrane. Cytoplasm. Cytoplasm > cytoskeleton. Nucleus. Concentrates at the leading edge of membrane structures involved in actin motility.
  • Information by UniProt
  • Database links
  • Alternative names
    • 600 kDa retinoblastoma protein associated factor antibody
    • 600 kDa retinoblastoma protein-associated factor antibody
    • E3 ubiquitin-protein ligase UBR4 antibody
    • KIAA0462 antibody
    • KIAA1307 antibody
    • N-recognin-4 antibody
    • p600 antibody
    • RBAF600 antibody
    • Retinoblastoma associated factor 600 like protein antibody
    • Retinoblastoma associated factor of 600 kDa antibody
    • Retinoblastoma-associated factor 600 antibody
    • Retinoblastoma-associated factor of 600 kDa antibody
    • Ubiquitin protein ligase E3 component n recognin 4 antibody
    • UBR4 antibody
    • UBR4_HUMAN antibody
    • Zinc finger UBR1 type protein 1 antibody
    • Zinc finger UBR1-type protein 1 antibody
    • Zinc finger, UBR1 type 1 antibody
    • ZUBR 1 antibody
    • ZUBR1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed and paraffin embedded Human spleen tissue labeling UBR4 with ab187879 at 

    5μg/ml dilution.

References

ab187879 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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