Overview

  • Product nameAnti-UCHL3 antibody
    See all UCHL3 primary antibodies
  • Description
    Mouse monoclonal to UCHL3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: PEERARYLEN YDAIRVTHET SAHEGQTEAP SIDEKVDLHF IALVHVDGHL YELDGRKPFP INHGETSDET LLEDAIEVCK KFMERDPDEL RFNAIALSAA , corresponding to amino acids 131-231 of Human UCHL3

Properties

Applications

Our Abpromise guarantee covers the use of ab57689 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDeubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory.
    • Tissue specificityHighly expressed in heart, skeletal muscle, and testis.
    • Sequence similaritiesBelongs to the peptidase C12 family.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody
      • Ubiquitin thioesterase L3 antibody
      • Ubiquitin thiolesterase antibody
      • Ubiquitin thiolesterase L3 antibody
      • UCH L3 antibody
      • UCH-L3 antibody
      • UCHL3 antibody
      • UCHL3_HUMAN antibody
      see all

    Anti-UCHL3 antibody images



    • Predicted band size : 26 kDa
      UCHL3 antibody (ab57689) at 1ug/lane + K-562 cell lysate at 25ug/lane.

    References for Anti-UCHL3 antibody (ab57689)

    This product has been referenced in:
    • Trott D  et al. Effect of phosphorylated hsp27 on proliferation of human endothelial and smooth muscle cells. Proteomics 9:3383-94 (2009). Read more (PubMed: 19562804) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"