Overview

  • Product name
  • Description
    Rabbit polyclonal to UFD1L
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to C terminal residues of UFD1L (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab56208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.

Target

  • Function
    Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
  • Tissue specificity
    Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
  • Pathway
    Protein degradation; proteasomal ubiquitin-dependent pathway.
  • Sequence similarities
    Belongs to the UFD1 family.
  • Cellular localization
    Nucleus. Cytoplasm > cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • UB fusion protein 1 antibody
    • Ubiquitin fusion degradation 1 like (yeast) antibody
    • Ubiquitin fusion degradation 1 like antibody
    • Ubiquitin fusion degradation protein 1 homolog antibody
    • UFD1 antibody
    • UFD1_HUMAN antibody
    • UFD1L antibody
    see all

References for Anti-UFD1L antibody (ab56208)

ab56208 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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