• Product name
  • Description
    Rabbit polyclonal to UGT1A4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 59-108 (VVLTPEVNMH IKEEKFFTLT AYAVPWTQKE FDRVTLGYTQ GFFETEHLLK) of Human UGT1A4 (NP_009051).

  • Positive control
    • HepG2 cell lysate.



Our Abpromise guarantee covers the use of ab105781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.
  • Tissue specificity
    Expressed in liver. Not expressed in skin or kidney.
  • Involvement in disease
    Defects in UGT1A4 are the cause of Gilbert syndrome (GILBS) [MIM:143500]. Gilbert syndrome occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague nonspecific complaints.
    Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 1 (CN1) [MIM:218800]. CN1 patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive.
    Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 2 (CN2) [MIM:606785]. CN2 patients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant.
  • Sequence similarities
    Belongs to the UDP-glycosyltransferase family.
  • Cellular localization
    Microsome. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bilirubin UDP glucuronosyltransferase isozyme 2 antibody
    • Bilirubin-specific UDPGT isozyme 2 antibody
    • HUG-BR2 antibody
    • UD14_HUMAN antibody
    • UDP glucuronosyltransferase 1 family polypeptide A4 antibody
    • UDP glycosyltransferase 1 family polypeptide A4 antibody
    • UDP-glucuronosyltransferase 1-4 antibody
    • UDP-glucuronosyltransferase 1-D antibody
    • UDP-glucuronosyltransferase 1A4 antibody
    • UDPGT 1-4 antibody
    • UDPGT antibody
    • UGT-1D antibody
    • UGT1*4 antibody
    • UGT1-04 antibody
    • UGT1.4 antibody
    • UGT1A4 antibody
    • UGT1D antibody
    see all

Anti-UGT1A4 antibody images

  • Anti-UGT1A4 antibody (ab105781) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 60 kDa

References for Anti-UGT1A4 antibody (ab105781)

ab105781 has not yet been referenced specifically in any publications.

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