Overview

  • Product nameAnti-UHRF1 antibody
    See all UHRF1 primary antibodies
  • Description
    Rabbit polyclonal to UHRF1
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the central region of Human UHRF1.

  • Positive control
    • HeLa cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab93419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 90 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPutative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
    • Tissue specificityExpressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesContains 1 PHD-type zinc finger.
      Contains 2 RING-type zinc fingers.
      Contains 1 ubiquitin-like domain.
      Contains 1 YDG domain.
    • Developmental stageExpressed in fetal thymus, liver and kidney.
    • DomainThe RING finger is required for ubiquitin ligase activity.
      The YDG domain mediates the interaction with histone H3.
    • Post-translational
      modifications
      Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.
      Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Ac2-121 antibody
      • AL022808 antibody
      • E3 ubiquitin-protein ligase UHRF1 antibody
      • EC 6.3.2.- antibody
      • FLJ21925 antibody
      • hNP95 antibody
      • hUHRF1 antibody
      • HuNp95 antibody
      • ICBP90 antibody
      • Inverted CCAAT box binding protein of 90 kDa antibody
      • Inverted CCAAT box binding protein, 90-kD antibody
      • Inverted CCAAT box-binding protein of 90 kDa antibody
      • Liver regeneration-related protein LRRG126 antibody
      • MGC138707 antibody
      • NP95 antibody
      • Nuclear phosphoprotein, 95-KD antibody
      • Nuclear protein 95 antibody
      • Nuclear zinc finger protein Np95 antibody
      • RING finger protein 106 antibody
      • RNF106 antibody
      • Transcription factor ICBP90 antibody
      • Ubiquitin like containing PHD and RING finger domains protein 1 antibody
      • Ubiquitin like PHD and RING finger domain containing protein 1 antibody
      • Ubiquitin-like PHD and RING finger domain-containing protein 1 antibody
      • Ubiquitin-like protein containing PHD and RING finger domains 1 antibody
      • Ubiquitin-like with PHD and ring finger domains 1 antibody
      • Ubiquitin-like, containing PHD and RING finger domains, 1 antibody
      • Ubiquitin-like-containing PHD and RING finger domains protein 1 antibody
      • UHRF1 antibody
      • UHRF1_HUMAN antibody
      see all

    Anti-UHRF1 antibody images

    • Anti-UHRF1 antibody (ab93419) at 1/100 dilution + HeLa cell lysate at 35 µg

      Predicted band size : 90 kDa

    References for Anti-UHRF1 antibody (ab93419)

    ab93419 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab93419.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"