Anti-ULBP1 antibody [MM0592-10K10] (ab89929)

Overview

  • Product name
    Anti-ULBP1 antibody [MM0592-10K10]
    See all ULBP1 primary antibodies
  • Description
    Mouse monoclonal [MM0592-10K10] to ULBP1
  • Tested applications
    Suitable for: Neutralising, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human protein.

  • General notes


    Suitable for neutralization of ligand-receptor interaction.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Primary antibody notes
    Suitable for neutralization of ligand-receptor interaction.
  • Clonality
    Monoclonal
  • Clone number
    MM0592-10K10
  • Isotype
    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab89929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Neutralising Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/100. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • Tissue specificity
    Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • Sequence similarities
    Belongs to the MHC class I family.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum. Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alcan beta antibody
    • ALCAN-beta antibody
    • N2DL-1 antibody
    • N2DL1 antibody
    • N2DL1_HUMAN antibody
    • NKG2D ligand 1 antibody
    • NKG2D ligand 1 precursor antibody
    • NKG2DL1 antibody
    • RAET1I antibody
    • Retinoic acid early transcript 1I antibody
    • UL16 antibody
    • UL16 binding protein 1 antibody
    • UL16-binding protein 1 antibody
    • ULBP1 antibody
    see all

References

ab89929 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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