Overview

  • Product nameAnti-ULBP2 antibody [MM0593-7F33]
    See all ULBP2 primary antibodies
  • Description
    Mouse monoclonal [MM0593-7F33] to ULBP2
  • Tested applicationsSuitable for: Neutralising, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant Human ULBP2 protein

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter.
  • ClonalityMonoclonal
  • Clone numberMM0593-7F33
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab89930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Neutralising Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/100. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • FunctionLigand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • Tissue specificityExpressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
  • Sequence similaritiesBelongs to the MHC class I family.
  • Cellular localizationCell membrane. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALCAN alpha antibody
    • ALCAN-alpha antibody
    • N2DL 2 antibody
    • N2DL-2 antibody
    • N2DL2 antibody
    • N2DL2_HUMAN antibody
    • NKG2D ligand 2 antibody
    • NKG2D ligand 2 precursor antibody
    • NKG2DL2 antibody
    • RAET1H antibody
    • Retinoic acid early transcript 1 H antibody
    • Retinoic acid early transcript 1H antibody
    • UL16 binding protein 2 antibody
    • UL16-binding protein 2 antibody
    • ULBP2 antibody
    see all

References for Anti-ULBP2 antibody [MM0593-7F33] (ab89930)

This product has been referenced in:

See 1 Publication for this product

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The isotyp is IgG2a.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"