Anti-UNC13B antibody (ab97664)
Key features and details
- Rabbit polyclonal to UNC13B
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-UNC13B antibody
See all UNC13B primary antibodies -
Description
Rabbit polyclonal to UNC13B -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Zebrafish -
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 462 and 719 of Human UNC13B (NP_006368)
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Positive control
- 293T and HeLa cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab97664 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 181 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 181 kDa. |
Target
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Function
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. -
Tissue specificity
Expressed in kidney cortical epithelial cells and brain. -
Sequence similarities
Belongs to the unc-13 family.
Contains 3 C2 domains.
Contains 1 MHD1 (MUNC13 homology domain 1) domain.
Contains 1 MHD2 (MUNC13 homology domain 2) domain.
Contains 1 phorbol-ester/DAG-type zinc finger. -
Domain
The C2 domains are not involved in calcium-dependent phospholipid binding. -
Cellular localization
Cytoplasm. Membrane. Cell membrane. Cell junction > synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding. - Information by UniProt
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Database links
- Entrez Gene: 10497 Human
- Entrez Gene: 22249 Mouse
- Entrez Gene: 64830 Rat
- Omim: 605836 Human
- SwissProt: O14795 Human
- SwissProt: Q9Z1N9 Mouse
- SwissProt: Q62769 Rat
- Unigene: 493791 Human
see all -
Alternative names
- hmunc13 antibody
- MGC133279 antibody
- MGC133280 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab97664 has been referenced in 1 publication.
- Wang XB et al. UNC13B Promote Arsenic Trioxide Resistance in Chronic Lymphoid Leukemia Through Mitochondria Quality Control. Front Oncol 12:920999 (2022). PubMed: 35707364