Overview

  • Product name
  • Description
    Rabbit polyclonal to UNC13B
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Zebrafish
  • Immunogen

    Recombinant protein fragment corresponding to a region within amino acids 680 and 927 of Human UNC13B (NP_006368)

  • Positive control
    • 293T, H1299, HeLa or HepG2 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab97924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 181 kDa.

Target

  • Function
    Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
  • Tissue specificity
    Expressed in kidney cortical epithelial cells and brain.
  • Sequence similarities
    Belongs to the unc-13 family.
    Contains 3 C2 domains.
    Contains 1 MHD1 (MUNC13 homology domain 1) domain.
    Contains 1 MHD2 (MUNC13 homology domain 2) domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
  • Domain
    The C2 domains are not involved in calcium-dependent phospholipid binding.
  • Cellular localization
    Cytoplasm. Membrane. Cell membrane. Cell junction > synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
  • Information by UniProt
  • Database links
  • Alternative names
    • hmunc13 antibody
    • MGC133279 antibody
    • MGC133280 antibody
    • munc13 antibody
    • Munc13-2 antibody
    • Protein unc-13 homolog B antibody
    • UN13B_HUMAN antibody
    • unc-13 homolog B (C. elegans) antibody
    • UNC13 antibody
    • Unc13b antibody
    • Unc13h2 antibody
    see all

Images

  • Anti-UNC13B antibody (ab97924) at 1/500 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 181 kDa

References

ab97924 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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