Overview

  • Product name
  • Description
    Goat polyclonal to UNC5C
  • Tested applications
    Suitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Chicken, Hamster, Cow, Dog, Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human UNC5C aa 812-823 (internal sequence).
    Sequence:

    NCTVSEEPTGID


    Database link: O95185

  • Positive control
    • Human cortex tissue, Mouse Pancreas

Properties

Applications

Our Abpromise guarantee covers the use of ab189348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC/IF Use a concentration of 50 µg/ml.
WB Use at an assay dependent concentration. Predicted molecular weight: 103 kDa.

Target

  • Function
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
  • Tissue specificity
    Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.
  • Sequence similarities
    Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • Post-translational
    modifications
    Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • homolog of C. elegans transmembrane receptor Unc5 antibody
    • Netrin receptor UNC5C antibody
    • Protein unc 5 homolog C antibody
    • Protein unc-5 homolog 3 antibody
    • Protein unc-5 homolog C antibody
    • Unc 5 homolog 3 antibody
    • Unc 5 homolog C antibody
    • Unc5 (C.elegans homolog) c antibody
    • Unc5c antibody
    • UNC5C_HUMAN antibody
    • UNC5H3 antibody
    see all

Images

  • Immunofluorescence analysis of Mouse Pancreas labeling UNC5C with ab189348 at 50 µg/ml.

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Human cortex tissue labeling UNC5C with ab189348 at 3.75 µg/ml.

References

ab189348 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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