Overview

  • Product name
  • Description
    Rabbit polyclonal to UNC80
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: KDSLNNVVDF LHALLGFCME PVTDNKAGFG NNFTTVDNKS TAQNVEGIIV SAMFKSLITR CASTTHELHS PENLGLYCDI RQLVQFIKEA HGNVFR, corresponding to amino acids of Human UNC80.

  • Positive control
    • Human hippocampus tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab126312 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.
  • Sequence similarities
    Belongs to the unc-80 family.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C2orf21 antibody
    • Protein unc-80 homolog antibody
    • UNC 80 antibody
    • Unc 80 homolog (C. elegans) antibody
    • Unc80 antibody
    • UNC80_HUMAN antibody
    see all

Images

  • ab126312 at 1/50 dilution staining UNC80 in Paraffin-embedded Human hippocampus tissue by Immunohistochemistry.

References

This product has been referenced in:
  • Perez Y  et al. UNC80 mutation causes a syndrome of hypotonia, severe intellectual disability, dyskinesia and dysmorphism, similar to that caused by mutations in its interacting cation channel NALCN. J Med Genet 53:397-402 (2016). Read more (PubMed: 26545877) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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