This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

  • Application notesThis antibody gave a positive result in ELISA against the immunizing peptide (ab45333).
    Not yet tested in other applications.
  • Target

    • RelevanceUPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. UPF3B binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X (referenced from entrez gene).
    • Cellular localizationNucleus. Cytoplasm. Note: Shuttling between the nucleus and the cytoplasm.
    • Database links
    • Alternative names
      • HUPF3B antibody
      • hUpf3p X antibody
      • MRXS14 antibody
      • Nonsense mRNA reducing factor 3B antibody
      • Regulator of nonsense transcripts 3B antibody
      • RENT3B antibody
      • Up-frameshift suppressor 3 homolog B antibody
      • Up-frameshift suppressor 3 homolog on chromosome X antibody
      • UPF3 regulator of nonsense transcripts homolog B (yeast) antibody
      • UPF3 regulator of nonsense transcripts homolog B antibody
      • UPF3B antibody
      • UPF3X antibody
      see all

    References for Anti-UPF3B/RENT3B antibody (ab42731)

    ab42731 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"