The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Detects a band of approximately 39 kDa (predicted molecular weight: 60 kDa).
Use at an assay dependent dilution.
FunctionFunctions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Tissue specificityExpressed in adrenal tissue, JEG-3, NCI-H295A, HepG2 and HeLa cell lines.
Sequence similaritiesBelongs to the grh/CP2 family. CP2 subfamily.