Overview

  • Product name
  • Description
    Rabbit polyclonal to UQCRB
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    antigen sequence: LPENLYNDRM FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K, corresponding to internal sequence amino acids 51-111 of Human UQCRB.

  • Positive control
    • Human colon tissue; RT 4, U 251 MG and Liver lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab122827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function
    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.
  • Involvement in disease
    Defects in UQCRB are a cause of mitochondrial complex III deficiency (MT-C3D) [MIM:124000]. A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.
  • Sequence similarities
    Belongs to the UQCRB/QCR7 family.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Complex III subunit 7 antibody
    • Complex III subunit VII antibody
    • Cytochrome b-c1 complex subunit 7 antibody
    • MC3DN3 antibody
    • Mitochondrial ubiquinone-binding protein antibody
    • QCR7 antibody
    • QCR7_HUMAN antibody
    • QP-C antibody
    • QPC antibody
    • Ubiquinol cytochrome c reductase complex III subunit VI antibody
    • Ubiquinol-cytochrome c reductase binding protein antibody
    • Ubiquinol-cytochrome c reductase complex 14 kDa protein antibody
    • Ubiquinone-binding protein antibody
    • UQBC antibody
    • UQBP antibody
    • UQCR6 antibody
    • UQCRB antibody
    • UQPC antibody
    see all

Images

  • All lanes : Anti-UQCRB antibody (ab122827) at 1/250 dilution

    Lane 1 : RT 4 lysate
    Lane 2 : U 251 MG lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique
  • ab122827 at 1/200 dilution staining UQCRB in Paraffin-embedded Human colon tissue by Immunohistochemistry tissue.

References

ab122827 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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