Biological descriptionReported potent and non-competitive monoacylglycerol lipase (MAGL) inhibitor (IC50 = 200 nM). Inhibits FAAH (IC50 = 32 µM) and binds weakly to the rat CB1 receptor (IC50 = 3.8 µM). Shows vasodilatory activity.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Hillard CJ et al. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. Br J Pharmacol152:691-8 (2007).
Read more (PubMed: 17891162) »
Saario SM et al. URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. Chem Biol13:811-4 (2006).
Read more (PubMed: 16931330) »
Makara JK et al. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci8:1139-41 (2005).
Read more (PubMed: 16116451) »