1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionMay be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.
Tissue specificityStrongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.
Sequence similaritiesBelongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family. Contains 1 VLIG-type G (guanine nucleotide-binding) domain.
Cellular localizationCytoplasm. Nucleus. In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.