Overview

  • Product name
    Anti-Urokinase antibody [H77A10]
    See all Urokinase primary antibodies
  • Description
    Mouse monoclonal [H77A10] to Urokinase
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Mouse uPA

  • General notes


    This antibody was produced in a knockout mouse.

Properties

Applications

Our Abpromise guarantee covers the use of ab28230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Use under non reducing condition. Predicted molecular weight: 48 kDa.
ELISA Use at an assay dependent dilution.

Target

  • Function
    Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
  • Tissue specificity
    Expressed in the prostate gland and prostate cancers.
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 1 EGF-like domain.
    Contains 1 kringle domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
    • Alternative names
      • ATF antibody
      • ATF uPA antibody
      • BDPLT5 antibody
      • Plasminogen activator antibody
      • Plasminogen activator urinary antibody
      • Plasminogen activator urokinase antibody
      • PLAU antibody
      • QPD antibody
      • u PA antibody
      • U plasminogen activator antibody
      • u-PA antibody
      • U-plasminogen activator antibody
      • uPA antibody
      • URK antibody
      • UROK_HUMAN antibody
      • Urokinase plasminogen activator antibody
      • Urokinase type plasminogen activator antibody
      • Urokinase type plasminogen activator precursor antibody
      • Urokinase-type plasminogen activator chain B antibody
      see all

    Images

    • Western blot - Anti-Urokinase antibody [H77A10] (ab28230)
      Western blot - Anti-Urokinase antibody [H77A10] (ab28230)
      All lanes : Anti-Urokinase antibody [H77A10] (ab28230) at 3 µg/ml

      Lane 1 : Mouse Urokinase (0.5ug)
      Lane 2 : MUPA (0.5ug) + CPAI (2.5ug)
      Lane 3 : Prestained standard

      Performed under non-reducing conditions.

      Predicted band size: 48 kDa

    References

    This product has been referenced in:
    • Krause MP  et al. Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice. Diabetes 60:1964-72 (2011). WB ; Mouse . Read more (PubMed: 21593201) »
    • Khanna A  et al. Ets-1 expression and gemcitabine chemoresistance in pancreatic cancer cells. Cell Mol Biol Lett 16:101-13 (2011). WB ; Human . Read more (PubMed: 21225469) »

    See all 2 Publications for this product

    Publishing research using ab28230? Please let us know so that we can cite the reference in this datasheet.

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