Anti-Uromucoid antibody (ab53588)

Overview

  • Product nameAnti-Uromucoid antibody
    See all Uromucoid primary antibodies
  • Description
    Sheep polyclonal to Uromucoid
  • Tested applicationsSuitable for: ELISA, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Uromucoid, purified from urine

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% EACA, 0.01% Benzamidine, Glycine buffered saline, 1mM EDTA, pH 7.4
  • Concentration information loading...
  • PurityAmmonium Sulphate Precipitation
  • Purification notesIg fraction prepared by ammonium sulphate fractionation.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab53588 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/10000 - 1/40000.
IHC-Fr 1/50 - 1/200.

Target

  • FunctionNot known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
  • Tissue specificitySynthesized by kidney. Most abundant protein in normal human urine.
  • Involvement in diseaseDefects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
    Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
    Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
  • Sequence similaritiesContains 3 EGF-like domains.
    Contains 1 ZP domain.
  • Cellular localizationCell membrane. Secreted. Secreted after cleavage in the urine.
  • Information by UniProt
  • Database links
  • Alternative names
    • ADMCKD2 antibody
    • FJHN antibody
    • HNFJ antibody
    • HNFJ1 antibody
    • MCKD2 antibody
    • medullary cystic kidney disease 2 (autosomal dominant) antibody
    • Tamm Horsfall glycoprotein antibody
    • Tamm Horsfall urinary glycoprotein antibody
    • Tamm-Horsfall urinary glycoprotein antibody
    • THGP antibody
    • THP antibody
    • Umod antibody
    • Urehd1 antibody
    • urehr4 antibody
    • UROM_HUMAN antibody
    • uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody
    • Uromodulin antibody
    • Uromodulin, secreted form antibody
    see all

References for Anti-Uromucoid antibody (ab53588)

ab53588 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. This product is partially purified by ammonium sulfate precipitation. Due to the nature of this purification, an exact concentration can not be determined. However, an estimate of specific antibody present in this prepa...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"