Recombinant
Anti-Uroplakin III antibody [SP73], prediluted (ab101546)
- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-Uroplakin III antibody [SP73], prediluted
See all Uroplakin III primary antibodies -
DescriptionRabbit monoclonal [SP73] to Uroplakin III, prediluted
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Host speciesRabbit
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Tested applicationsSuitable for: IHC-Pmore details
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Species reactivityReacts with: Human
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Immunogen
Synthetic peptide within Human Uroplakin III (C terminal). The exact sequence is proprietary.
Database link: O75631 -
Positive control
- Human bladder carcinoma
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General notes
This product is a recombinant rabbit monoclonal antibody.
Properties
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FormPrediluted
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Storage bufferPreservative: 0.1% Sodium Azide
Constituents: 1% BSA, 50mM Tris, pH 7.6 -
Concentration information loading... -
Purification notesPurified from TCS by protein A/G.
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ClonalityMonoclonal
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Clone numberSP73
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IsotypeIgG
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Research areas
Associated products
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Alternative Versions
Applications
Our Abpromise guarantee covers the use of ab101546 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Prediluted and ready to use. |
Target
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FunctionComponent of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
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Tissue specificityExpressed in ureter.
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Involvement in diseaseDefects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.
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Sequence similaritiesBelongs to the uroplakin-3 family.
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Cellular localizationEndoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
- Information by UniProt
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Database links
- Entrez Gene: 7380 Human
- Omim: 611559 Human
- SwissProt: O75631 Human
- Unigene: 632787 Human
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Alternative names
- MGC119178 antibody
- OTTHUMP00000028951 antibody
- UP III antibody
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Images
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin III antibody [SP73], prediluted (ab101546)](http://a.abcam.com/ps/products/101/ab101546/Images/Uroplakin-III-Primary-antibodies-ab101546-1.JPG)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin III antibody [SP73], prediluted (ab101546)ab101546 staining formalin fixed and paraffin embedded Human bladder carcinoma tissue.
Protocols
References
ab101546 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"