Anti-Uroplakin III antibody [SP73], prediluted (ab101546)
- Datasheet
- Specific References
- Protocols
Overview
-
Product nameAnti-Uroplakin III antibody [SP73], prediluted
See all Uroplakin III primary antibodies -
DescriptionRabbit monoclonal [SP73] to Uroplakin III, prediluted
-
Tested applicationsSuitable for: IHC-Pmore details
-
Species reactivityReacts with: Human
-
Immunogen
A synthetic peptide corresponding to C-terminus of Human Uroplakin III
-
Positive control
- Human bladder carcinoma
-
General notes
This product is a recombinant rabbit monoclonal antibody.
Properties
-
FormPrediluted
-
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
-
Storage bufferPreservative: 0.1% Sodium Azide
Constituents: 1% BSA, 50mM Tris, pH 7.6 -
Concentration information loading... -
ClonalityMonoclonal
-
Clone numberSP73
-
IsotypeIgG
-
Research areas
Applications
Our Abpromise guarantee covers the use of ab101546 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Prediluted and ready to use. |
Target
-
FunctionComponent of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
-
Tissue specificityExpressed in ureter.
-
Involvement in diseaseDefects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.
-
Sequence similaritiesBelongs to the uroplakin-3 family.
-
Cellular localizationEndoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
- Information by UniProt
-
Database links
- Entrez Gene: 7380 Human
- Omim: 611559 Human
- SwissProt: O75631 Human
- Unigene: 632787 Human
-
Alternative names
- MGC119178 antibody
- OTTHUMP00000028951 antibody
- UP III antibody
see all
Anti-Uroplakin III antibody [SP73], prediluted images
-
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Uroplakin III antibody [SP73] (ab101546)](http://a.abcam.com/ps/datasheet/images/101/ab101546/Uroplakin-III-Primary-antibodies-ab101546-1.JPG)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Uroplakin III antibody [SP73] (ab101546)ab101546 staining formalin fixed and paraffin embedded Human bladder carcinoma tissue.
Protocols
References for Anti-Uroplakin III antibody [SP73], prediluted (ab101546)
ab101546 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"