FunctionRequired for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Tissue specificityExpressed in vestibule of the inner ear, eye and small intestine.
Cellular localizationCytoplasm > cytosol. Cytoplasm > cytoskeleton. Cell membrane. Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15.