Overview

  • Product nameAnti-USH2A antibody
    See all USH2A primary antibodies
  • Description
    Rabbit polyclonal to USH2A
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal domain of Human USH2A

Properties

Applications

Our Abpromise guarantee covers the use of ab82714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/2000. Predicted molecular weight: 576 kDa.

Target

  • RelevanceThe Usher 2A gene expresses an extra cellular matrix protein that resembles unconventional Myosin and do not appear to have any un-conventional functional correlations. It is expressed primarily in retina and cochlea and may be important in the development and homeostasis of the inner ear and retina. The human Usher Syndrome 2A (Ush2A) protein has several functional domains (Laminin type EGF like domain; Laminin-Type epidermal growth factor like domain and a fibronectin type 3 like domain). The protein has a single transmembrane domain that anchor the protein to the cell membrane, the rest of the protein stays outside the cell. Defects in the USH2A gene are the most common cause of deafness and blindness in adults and affect 3-6% children born with hearing impairments. The affected individuals have sensory-neural deficiencies at birth and subsequently develop progressive retinitis pigmentosa (RP). Three forms of Usher syndrome have been characterized, Usher Type 1, II and III which can be distinguish based on severity of hearing loss and vestibular involvement. Type I patents are profoundly deaf while type II (most common form of Usher syndrome) patients are mildly deaf but have normal in vestibular responses.
  • Cellular localizationCell Membrane; single-pass type I membrane protein. Isoform 2 is secreted.
  • Database links
  • Alternative names
    • dJ1111A8.1 antibody
    • US2 antibody
    • USH2A antibody
    • Usher syndrome type 2A protein antibody
    • Usher syndrome type IIa protein antibody
    • Usherin antibody
    see all

References for Anti-USH2A antibody (ab82714)

ab82714 has not yet been referenced specifically in any publications.

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