This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

Applications

  • Application notesThis antibody gave a positive result in ELISA against the immunizing peptide (ab28510).
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNegative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
    • Sequence similaritiesBelongs to the peptidase C19 family.
    • Developmental stageCell cycle-regulated. Highest level during S phase.
    • Post-translational
      modifications
      Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
      Ubiquitinated; leading to its subsequent proteasomal degradation.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deubiquitinating enzyme 1 antibody
      • hUBP antibody
      • Ubiquitin carboxyl terminal hydrolase 1 antibody
      • Ubiquitin carboxyl-terminal hydrolase 1 antibody
      • Ubiquitin specific peptidase 1 antibody
      • Ubiquitin specific protease 1 antibody
      • Ubiquitin thioesterase 1 antibody
      • Ubiquitin thiolesterase 1 antibody
      • Ubiquitin-specific-processing protease 1 antibody
      • UBP antibody
      • UBP1_HUMAN antibody
      • USP 1 antibody
      • Usp1 antibody
      see all

    Anti-USP1 antibody images

    This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

    • Immunofluorescence analysis of HEK293T cells, staining USP1 with ab27868 at 1/200 dilution.

    References for Anti-USP1 antibody (ab27868)

    This product has been referenced in:
    • Garcia-Santisteban I  et al. Two Nuclear Localization Signals in USP1 Mediate Nuclear Import of the USP1/UAF1 Complex. PLoS One 7:e38570 (2012). ICC/IF . Read more (PubMed: 22701671) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"