Overview

  • Product nameAnti-USP10 antibody
    See all USP10 primary antibodies
  • Description
    Rabbit polyclonal to USP10
  • Tested applicationsSuitable for: ICC, WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to N terminal residues of Human USP10 (CAB82392.2).

  • Positive control
    • Human brain (cortex), colon and breast tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab117606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 87 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionHydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the peptidase C19 family. USP10 subfamily.
  • Post-translational
    modifications
    Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.
  • Cellular localizationCytoplasm. Nucleus. Early endosome. Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.
  • Information by UniProt
  • Database links
  • Alternative names
    • Deubiquitinating enzyme 10 antibody
    • KIAA0190 antibody
    • MGC124997 antibody
    • MGC2621 antibody
    • Ubiquitin carboxyl terminal hydrolase 10 antibody
    • Ubiquitin carboxyl-terminal hydrolase 10 antibody
    • Ubiquitin specific peptidase 10 antibody
    • Ubiquitin specific processing protease 10 antibody
    • Ubiquitin specific protease 10 antibody
    • Ubiquitin thioesterase 10 antibody
    • Ubiquitin thiolesterase 10 antibody
    • Ubiquitin-specific-processing protease 10 antibody
    • UBP10_HUMAN antibody
    • UBPO antibody
    • USP 10 antibody
    • USP10 antibody
    see all

Anti-USP10 antibody images

  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Brain (cortex) tissue by Immunohistochemistry.
  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Breast tissue by Immunohistochemistry.
  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Colon tissue by Immunohistochemistry.

References for Anti-USP10 antibody (ab117606)

ab117606 has not yet been referenced specifically in any publications.

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