The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 120-130 kDa (predicted molecular weight: 110 kDa).Can be blocked with Human USP11 peptide (ab23087).
FunctionProtease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.
Sequence similaritiesBelongs to the peptidase C19 family. Contains 1 DUSP domain.
Cellular localizationNucleus. Cytoplasm. Predominantly nuclear. Associates with chromatin.