The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Detects a band of approximately 50 kDa (predicted molecular weight: 43 kDa).
FunctionDeubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
Sequence similaritiesBelongs to the peptidase C19 family. USP12/USP46 subfamily.