Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionDeubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates.
Sequence similaritiesBelongs to the peptidase C19 family. Contains 2 CS domains. Contains 1 MYND-type zinc finger.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Immunohistochemistry analysis of paraffin-embedded
human breast carcinoma tissue using ab93159
References for Anti-USP19 antibody (ab93159)
This product has been referenced in:
Ogawa M et al. 17ß-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor a. J Biol Chem286:41455-65 (2011).
Read more (PubMed: 21971047) »