Overview

  • Product nameAnti-USP20 antibody
    See all USP20 primary antibodies
  • Description
    Mouse monoclonal to USP20
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: VATVALTEAR DSDSSDTDEK REGDRSPSED EFLSCDSSSD RGEGDGQGRG GGSSQAETEL LIPDEAGRAI SEKERMKDRK FSWGQQRTNS EQVDEDAD, corresponding to amino acids 252-350 of Human USP20

Properties

Applications

Our Abpromise guarantee covers the use of ab56789 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDeubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
    • Sequence similaritiesBelongs to the peptidase C19 family. USP20/USP33 subfamily.
      Contains 2 DUSP domains.
      Contains 1 UBP-type zinc finger.
    • DomainThe UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue.
    • Post-translational
      modifications
      Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
    • Cellular localizationCytoplasm > perinuclear region. According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deubiquitinating enzyme 20 antibody
      • hVDU2 antibody
      • KIAA1003 antibody
      • LSFR 3A antibody
      • LSFR3A antibody
      • pVHL interacting deubiquitinating enzyme 2 antibody
      • Ubiquitin carboxyl terminal hydrolase 20 antibody
      • Ubiquitin carboxyl-terminal hydrolase 20 antibody
      • ubiquitin specific peptidase 20 antibody
      • Ubiquitin specific processing protease 20 antibody
      • Ubiquitin specific protease 20 antibody
      • Ubiquitin thioesterase 20 antibody
      • Ubiquitin thiolesterase 20 antibody
      • Ubiquitin-specific-processing protease 20 antibody
      • UBP20_HUMAN antibody
      • USP 20 antibody
      • USP20 antibody
      • VDU 2 antibody
      • VDU2 antibody
      • VHL interacting deubiquitinating enzyme 2 antibody
      • VHL-interacting deubiquitinating enzyme 2 antibody
      see all

    Anti-USP20 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56789 USP20 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-USP20 antibody (ab56789)

    ab56789 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab56789.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"