Overview

  • Product name
  • Description
    Rabbit polyclonal to USP21
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide within Human USP21 aa 232-262 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9UK80

  • Positive control
    • NCI-H460 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab174371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 62 kDa.

Target

  • Function
    Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
  • Tissue specificity
    Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
  • Sequence similarities
    Belongs to the peptidase C19 family. USP21 subfamily.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Deubiquitinating enzyme 21 antibody
    • deubiquitinating enzyme 23 antibody
    • EC 3.1.2.15 antibody
    • ESTM28 antibody
    • MGC3394 antibody
    • NEDD8-specific protease antibody
    • Ubiquitin carboxyl terminal hydrolase 21 antibody
    • ubiquitin carboxyl terminal hydrolase 23 antibody
    • Ubiquitin carboxyl-terminal hydrolase 21 antibody
    • ubiquitin specific peptidase 21 antibody
    • Ubiquitin specific processing protease 21 antibody
    • ubiquitin specific protease 16 antibody
    • ubiquitin specific protease 21 antibody
    • ubiquitin specific protease 23 antibody
    • Ubiquitin thioesterase 21 antibody
    • Ubiquitin thiolesterase 21 antibody
    • ubiquitin thiolesterase 23 antibody
    • ubiquitin-specific protease 23, formerly antibody
    • Ubiquitin-specific-processing protease 21 antibody
    • UBP21_HUMAN antibody
    • USP16 antibody
    • Usp21 antibody
    • USP23 antibody
    • USP23, formerly antibody
    • W53272 antibody
    see all

Images

  • Anti-USP21 antibody (ab174371) at 1/50 dilution + NCI-H460 cell lysate at 35 µg

    Predicted band size : 62 kDa

References

ab174371 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab174371.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up