Overview

  • Product nameAnti-USP21 antibody
    See all USP21 primary antibodies
  • Description
    Mouse monoclonal to USP21
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: FSASRGSIKK SSVGVDFPLQ RLSLGDFASD KAGSPVYQLY ALCNHSGSVH YGHYTALCRC QTGWHVYNDS RVSPVSENQV ASSEGYVLFY QLMQEPPRCL , corresponding to amino acids 466-566 of Human USP21

Properties

Applications

Our Abpromise guarantee covers the use of ab57184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDeubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
    • Tissue specificityHighly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
    • Sequence similaritiesBelongs to the peptidase C19 family. USP21 subfamily.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deubiquitinating enzyme 21 antibody
      • deubiquitinating enzyme 23 antibody
      • EC 3.1.2.15 antibody
      • ESTM28 antibody
      • MGC3394 antibody
      • NEDD8-specific protease antibody
      • Ubiquitin carboxyl terminal hydrolase 21 antibody
      • ubiquitin carboxyl terminal hydrolase 23 antibody
      • Ubiquitin carboxyl-terminal hydrolase 21 antibody
      • ubiquitin specific peptidase 21 antibody
      • Ubiquitin specific processing protease 21 antibody
      • ubiquitin specific protease 16 antibody
      • ubiquitin specific protease 21 antibody
      • ubiquitin specific protease 23 antibody
      • Ubiquitin thioesterase 21 antibody
      • Ubiquitin thiolesterase 21 antibody
      • ubiquitin thiolesterase 23 antibody
      • ubiquitin-specific protease 23, formerly antibody
      • Ubiquitin-specific-processing protease 21 antibody
      • UBP21_HUMAN antibody
      • USP16 antibody
      • Usp21 antibody
      • USP23 antibody
      • USP23, formerly antibody
      • W53272 antibody
      see all

    Anti-USP21 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57184 USP21 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-USP21 antibody (ab57184)

    This product has been referenced in:
    • Xu G  et al. Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. J Biol Chem 285:969-78 (2010). WB ; Human . Read more (PubMed: 19910467) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab57184.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"