Overview

  • Product name
    Anti-USP21 antibody - Aminoterminal end
    See all USP21 primary antibodies
  • Description
    Rabbit polyclonal to USP21 - Aminoterminal end
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Human
  • Immunogen

    Synthetic peptide within Mouse USP21 aa 51-100 (N terminal). The exact sequence is proprietary.
    Sequence:

    PLPPRPGPPDERLKKLELGRGRTSGSRPRGPLRADHGVPLPGSPPPAVAL


    Database link: NP_038947

  • Positive control
    • Mouse brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab171028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 63 kDa.

Target

  • Function
    Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
  • Tissue specificity
    Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
  • Sequence similarities
    Belongs to the peptidase C19 family. USP21 subfamily.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Deubiquitinating enzyme 21 antibody
    • deubiquitinating enzyme 23 antibody
    • EC 3.1.2.15 antibody
    • ESTM28 antibody
    • MGC3394 antibody
    • NEDD8-specific protease antibody
    • Ubiquitin carboxyl terminal hydrolase 21 antibody
    • ubiquitin carboxyl terminal hydrolase 23 antibody
    • Ubiquitin carboxyl-terminal hydrolase 21 antibody
    • ubiquitin specific peptidase 21 antibody
    • Ubiquitin specific processing protease 21 antibody
    • ubiquitin specific protease 16 antibody
    • ubiquitin specific protease 21 antibody
    • ubiquitin specific protease 23 antibody
    • Ubiquitin thioesterase 21 antibody
    • Ubiquitin thiolesterase 21 antibody
    • ubiquitin thiolesterase 23 antibody
    • ubiquitin-specific protease 23, formerly antibody
    • Ubiquitin-specific-processing protease 21 antibody
    • UBP21_HUMAN antibody
    • USP16 antibody
    • Usp21 antibody
    • USP23 antibody
    • USP23, formerly antibody
    • W53272 antibody
    see all

Images

  • Anti-USP21 antibody - Aminoterminal end (ab171028) at 1 µg/ml + mouse brain lysate at 10 µg

    Predicted band size : 63 kDa

References

This product has been referenced in:
  • Jin J  et al. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nat Commun 7:13594 (2016). Read more (PubMed: 27886188) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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