Overview

  • Product nameAnti-USP3 antibody
    See all USP3 primary antibodies
  • Description
    Rabbit polyclonal to USP3
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region between residues 471 and 521 of Human USP3 (AAD42992.1).

  • Positive control
    • Human Anaplastic Thyroid Carcinoma, Breast Carcinoma, Colon Carcinoma, Metastatic Lymph Node, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma and Stomach Adenocarcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionHydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
    • Tissue specificityExpressed in all tissues examined, with strongest expression in pancreas.
    • Sequence similaritiesBelongs to the peptidase C19 family. USP3 subfamily.
      Contains 1 UBP-type zinc finger.
    • DomainBoth protease activity and an intact zinc finger are required for H2A monodeubiquitination.
    • Cellular localizationNucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deubiquitinating enzyme 3 antibody
      • EC 3.1.2.15 antibody
      • SIH003 antibody
      • Ubiquitin carboxyl-terminal hydrolase 3 antibody
      • Ubiquitin specific peptidase 3 antibody
      • Ubiquitin specific processing protease 3 antibody
      • Ubiquitin Specific Protease 3 antibody
      • Ubiquitin thioesterase 3 antibody
      • Ubiquitin thiolesterase 3 antibody
      • Ubiquitin-specific-processing protease 3 antibody
      • UBP antibody
      • UBP3_HUMAN antibody
      • Usp3 antibody
      see all

    Anti-USP3 antibody images

    • ab84702, at 1/100 dilution, staining USP3 in formalin-fixed, paraffin-embedded human ovarian carcinoma by Immunohistochemistry using a Red fluorescent goat anti-rabbit IgG highly cross adsorbed Hilyte PlusTM 555 secondary antibody at a dilution of 1/100.
    • ab84702, at 1/500 dilution, staining USP3 in formalin-fixed, paraffin-embedded human ovarian carcinoma by Immunohistochemistry using DAB staining.
    • ab84702, at 1/100 dilution, staining USP3 in formalin-fixed, paraffin-embedded human pancreatic islet cell tumor by Immunohistochemistry using DAB staining.

    References for Anti-USP3 antibody (ab84702)

    ab84702 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"