Overview

  • Product name
    Anti-USP34 antibody
  • Description
    Rabbit polyclonal to USP34
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese hamster, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 3350 and the C-terminus (residue 3395) of Human USP34 (CAE51938.1).

  • Positive control
    • Human breast carcinoma and prostate carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab91617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.
    • Tissue specificity
      Expressed in brain at low level.
    • Sequence similarities
      Belongs to the peptidase C19 family.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deubiquitinating enzyme 34 antibody
      • FLJ43910 antibody
      • KIAA0570 antibody
      • KIAA0729 antibody
      • MGC104459 antibody
      • Ubiquitin carboxyl terminal hydrolase 34 antibody
      • Ubiquitin carboxyl-terminal hydrolase 34 antibody
      • Ubiquitin specific processing protease 34 antibody
      • Ubiquitin specific protease 34 antibody
      • Ubiquitin thioesterase 34 antibody
      • Ubiquitin thiolesterase 34 antibody
      • Ubiquitin-specific-processing protease 34 antibody
      • UBP34_HUMAN antibody
      • USP 34 antibody
      • Usp34 antibody
      see all

    Images

    • ab91617, at 1/250 dilution, staining USP34 in formalin-fixed paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry using DAB staining.
    • ab91617, at 1/250 dilution, staining USP34 in formalin-fixed paraffin-embedded Human prostate carcinoma tissue by Immunohistochemistry using DAB staining.

    References

    ab91617 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab91617.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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