Overview

  • Product nameAnti-USP9Y antibody
    See all USP9Y primary antibodies
  • Description
    Mouse monoclonal to USP9Y
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: AITHGSPVGG NDSQGQVLDG QSQHLFQQNQ TSSPDSSNEN SVATPPPEEQ GQGDAPPQHE DEEPAFPHTE LANLDDMINR PRWVVPVL, corresponding to amino acids 3-91 of Human USP9Y

Properties

Applications

Our Abpromise guarantee covers the use of ab56471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling.
    • Tissue specificityWidely expressed in embryonic and adult tissues.
    • Involvement in diseaseNote=USP9Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. However AZFa deletions resulting in complete loss of USP9Y have been also found in normospermic men (PubMed:19246359).
      Defects in USP9Y might be a cause of spermatogenic failure non-obstructive Y-linked (SFNOY) [MIM:415000]. It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=The role of USP9Y in spermatogenesis failure is uncertain. A 4-bp deletion in a splice-donor site, causing exon skipping and protein truncation has been observed in non-obstructive azoospermia (PubMed:10581029). However complete USP9Y deletion has been detected in individuals with no spermatogenic defects (PubMed:19246359).
    • Sequence similaritiesBelongs to the peptidase C19 family.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • AZF 1 antibody
      • AZF antibody
      • AZF1 antibody
      • AZFA antibody
      • Azoospermia factor 1 antibody
      • Deubiquitinating enzyme FAF Y antibody
      • Deubiquitinating enzyme FAF-Y antibody
      • DFFRY antibody
      • Fat facets like antibody
      • Fat facets like Drosophila antibody
      • Fat facets protein related Y linked antibody
      • Fat facets protein-related antibody
      • Probable ubiquitin carboxyl terminal hydrolase FAF Y antibody
      • Probable ubiquitin carboxyl-terminal hydrolase FAF-Y antibody
      • SP 3 antibody
      • SP3 antibody
      • SPGFY2 antibody
      • Ubiquitin specific peptidase 9 Y linked antibody
      • Ubiquitin specific processing protease FAF Y antibody
      • Ubiquitin specific protease 9 Y chromosome antibody
      • Ubiquitin thioesterase FAF Y antibody
      • Ubiquitin thiolesterase FAF-Y antibody
      • Ubiquitin-specific protease 9 antibody
      • Ubiquitin-specific-processing protease FAF-Y antibody
      • USP 10 antibody
      • USP 9Y antibody
      • USP10 antibody
      • USP9Y antibody
      • USP9Y_HUMAN antibody
      • Y chromosome antibody
      • Y-linked antibody
      see all

    Anti-USP9Y antibody images

    • Western blot against tagged recombinant protein immunogen using ab56471 USP9Y antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    References for Anti-USP9Y antibody (ab56471)

    ab56471 has not yet been referenced specifically in any publications.

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